Multimodality Detection of Metastatic Melanoma

CyberKnife® Treatment of Metastatic Malignant Melanoma as Part of a Multimodality Therapy

Metastatic malignant melanoma is an incurable disease with a median survival of 8.5 months and a probability of surviving five years after the diagnosis of less than 5%. To date, no systemic therapy has meaningfully changed these survival end points. A case of metastatic melanoma treated with combined modalities including image-guided robotic radiosurgery with CyberKnife® (Accuray Incorporated,...

Fulminant hepatic failure due to metastatic choroidal melanoma

Detection of Occult Metastatic Melanoma by Urine Chromatography1

melanogenumia occurs in only a small proportion of mela noma patients, usually terminal, who survive long enough to develop the requisite tumor burden. The occurrence in the blood or urine of compounds that are involved in mela nm synthesis (on possibly in pigment hydrolysis) has long provided a theoretical model for an approach to detecting occult metastases and estimating the tumor burden in ...

Improved detection of metastatic melanoma by T2*-weighted imaging.

BACKGROUND AND PURPOSE The imaging features of metastatic melanomas are distinctive due to the presence of melanin and the propensity for hemorrhage. Both hemorrhage and melanin can produce T1-weighted hyperintensity and T2*-weighted signal intensity loss. We hypothesized that T2*-weighted images would improve detection of metastatic melanoma. METHODS The T2* and T1 characteristics of 120 new...

Detection of occult metastatic melanoma by urine chromatography.

By using ion-exchange column chromatography with effluent monitoring using the stable, free radical alpha,alpha-diphenyl-beta-picryhydrazyl as a colorimetric reagent, we have demonstrated the occurrence of elevated levels of five peaks in the urine of patients with metastatic disease. The tentative assignment of two of the peaks as 3,4-dihydroxyphenylalanine and as 3-methoxy-4-hydroxyphenylalan...